Xiaoyong Yang
Dr. Xiaoyong Yang is an Associate Professor of Comparative Medicine and of Cellular & Molecular Physiology at Yale University School of Medicine. He received B.S. from Nankai University, M.S. from Peking University, and Ph.D. from University of Alabama at Birmingham. He completed his postdoctoral training with Dr. Ronald Evans at Howard Hughes Medical Institute and The Salk Institute. Dr. Yang is an Associate Editor of Frontiers in Endocrinology and an Editorial Board Member of Journal of Biological Chemistry. He serves on scientific review committees for the NIDDK, NIGMS, NASA, American Diabetes Association, American Cancer Society, The Medical Research Council, The Wellcome Trust, National Natural Science Foundation of China, etc. His laboratory currently studies the role of protein post-translational modifications in cell signaling, gene regulation, metabolic physiology, and human disease. Representative recent publications:
1. Yang Y, Fu M, Li MD, Zhang K, Zhang B, Wang S, Liu Y, Ni W, Ong Q, Mi J, Yang X. O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity. Nat. Commun. (In press)
2. Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. JCI Insight 2019, 4:e127709.
3. Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat. Commun. 2018, 9:5103.
4. Yang X, Kevin Q. Protein O-GlcNAcylation: emerging mechanisms and functions. Nat. Rev. Mol. Cell Biol. 2017, 18:452-65.