Publications

2021

Chen lab: Zhou D, Feng H, Yang Y, et al. hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome. Circulation. 2021;144:1145. https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.121.054744

Chen lab: Tang X, Uhl S, Zhang T, et al. SARS-CoV-2 infection induces beta cell transdifferentiation, Cell Metabolism, 2021;33:1577. https://doi.org/10.1016/j.cmet.2021.05.015

Li lab: Xin H, Deng F, Zhou M, et al. A multi-tissue multi-omics analysis reveals distinct kinetics in entrainment of diurnal transcriptomes by inverted feeding. iScience 2021; 24:102335. https://doi.org/10.1016/j.isci.2021.102335

Li lab: Xin H, Huang R, Zhou M, et al. Protocol for setup and circadian analysis of inverted feeding in mice. STAR Protoc 2021; 2:100701. https://doi.org/10.1016/j.xpro.2021.100701

Li lab: Li M-D, Xin H, Yuan Y, et al. Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease. Front Genet 2021; 12. https://www.frontiersin.org/articles/10.3389/fgene.2021.721231/full

Gupta lab: Shao, M., Chelsea, H., Zhang, Q., et al. Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity. Published: February 03,  2021. https://doi.org/10.1016/j.stem.2020.12.008

Zhang lab: Xu, Y., Li, Y., Jadhav, K., et al. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Nat Metab 3, 59–74 (2021). https://doi.org/10.1038/s42255-020-00331-1

2020

Liu lab: Wang, L., Luo, Y., Luo, L., et al. Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling. J Exp Med 218 (2): e20190154. 2021. https://doi.org/10.1084/jem.20191054

Chen lab: Xu, L., Liu, X., Peng, F. et al. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol 22, 1162–1169 (2020). https://doi.org/10.1038/s41556-020-00581-x

Ruan lab: Zhao, M., Ren, K., Xiong, X., et al. Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells. Cell Reports, 2020. 32(6): 108013. https://doi.org/10.1016/j.celrep.2020.108013.

Kong lab: Zhu, X., Yao, T., Wang, R., et al. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Adv. Sci. 2020, 7, 2001502. https://doi.org/10.1002/advs.202001502

Tong lab: Zhu, C., Jiang, Z., Xu, Y. et al. Profound and redundant functions of arcuate neurons in obesity development. Nat Metab 2, 763–774 (2020). https://doi.org/10.1038/s42255-020-0229-2

Chen lab: Tang, X., Miao Y., Luo, Y., et al. Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction. Circulation. 2020;142:365–379. https://doi.org/10.1161/CIRCULATIONAHA.119.041231

Yang lab: Yang, Y., Li, X., Luan, H.H., et al. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. PNAS 117 (28) 16616-16625 (2020). https://doi.org/10.1073/pnas.1916121117

Xu lab: He, Y., Xu, P., Wang, C. et al. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun 11, 2165 (2020). https://doi.org/10.1038/s41467-020-15982-7

Lee lab: Knudsen NH, Stanya KJ, Hyde AL et al. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science 2020 May 1;368(6490). pii: eaat3987. doi: 10.1126/science.aat3987

Qi lab: Zhou Z, Torres M, Sha H et al. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science 2020 Apr 3;368(6486):54-60. doi: 10.1126/science.aay2494

Wang lab: Tran, D.H., May, H.I., Li, Q. et al. Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling. Nat Commun 11, 1771 (2020). https://doi.org/10.1038/s41467-020-15640-y

Wang lab: Mutlu, A.S., Gao, S.M., Zhang, H. et al. Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegansNat Commun 11, 1450 (2020). https://doi.org/10.1038/s41467-020-15296-8

Rui lab: Liu, Y., Lin, H., Jiang, L. et al. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. J Clin Invest. 2020. doi.org/10.1172/JCI128073

Huang lab: Li, D., Cao, T., Sun, X. et al. Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform. Nat Commun 11, 342 (2020) doi:10.1038/s41467-019-14185-z

Sun lab: Siang, D.T.C., Lim, Y.C., Kyaw, A.M.M. et al. The RNA-binding protein HuR is a negative regulator in adipogenesis. Nat Commun 11, 213 (2020) doi:10.1038/s41467-019-14001-8

Yang lab: Yang, Y., Fu, M., Li, M. et al. O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity. Nat Commun 11, 181 (2020) doi:10.1038/s41467-019-13914-8

2019

Qi lab: Ji, Y.*, Sun, S.*, Shrestha, N., Darragh, L., Shirakawa, J., Xing, Y., He, Y., Carboneau, B.A., Kim, H., Oberhozler, J., Soleimanpour, S.A., Gannon, M., Liu, C., Naji, A., Kulkarni, R., Wang, Y., Kersten, S., and Qi, L. 2019. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 20: 676-686. PMID: 31110312.

Yang lab: Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. JCI Insight 2019, 4:e127709. doi: 10.1172/jci.insight.127709.