News
Dr. Hai-Bin Ruan’s group uncovered a regulatory role for intestinal O-GlcNAcylation in linking dietary and gut microbial cues to L cell differentiation
Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells A recent publication in Cell Reports by Drs. Ming Zhao and Hai-Bin Ruan at the University of Minnesota, twin cities employed cutting-edge molecular...
A novel factor in controlling exercise capacity, IRF4, was discovered by a collaborative work by CADA members
IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway In a recent paper in Advanced Science by Drs. Xingxing Kong, Tiemin Liu, and John Zhong Li, an novel role of IRF4 in controlling muscle glycogen synthesis and exercise capacity was...
Research from CADA members demonstrated an important role of PVH in orchestrating diurnal rhythms in metabolism, feeding, and locomotion
Paraventricular hypothalamus mediates diurnal rhythm of metabolism A collaborative work from Drs. Qingchun Tong and Yong Xu identified an important role of PVH to orchestrate diurnal rhythms in metabolism, feeding, and locomotion, that was recently published in Nature...
CADA rising star member led a study revealing an unexpected role of liver clock in body rhythms and metabolic health
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types Dr. Dongyin Guan, a rising star member of CADA, led an striking study recently published in Science, revealing an unexpected role of liver clock in body rhythms and metabolic...
Postdoctoral Position in Yang Lab, Yale University School of Medicine
A postdoctoral position is available for a highly motivated individual in the laboratory of Dr. Xiaoyong Yang at Yale University School of Medicine. The Yang laboratory studies the mechanisms that regulate organ physiology and human diseases including diabetes,...
Novel studies from CADA members provided a comprehensive understanding of causal relationships between NAFLD, T2D and obesity
Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping Non-alcoholic fatty liver disease, type 2 diabetes and obesity are epidemiologically correlated with each other, but their causal relationships were incompletely...
Dr. Qingchun Tong’s group uncovered a redundant role for arcuate GABA+ neurons in appetite control and obesity
Profound and redundant functions of arcuate neurons in obesity development A recent publication in Nature Metabolism by Drs. Canjun Zhu, Gang Shu, and Qingchun Tong at UT Health Science Center at Houston employed an elegant subtractive approach to determine whether...
A novel mechanism underlying endothelial cell communication with adipose tissues was discovered by CADA members
Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction A recent study published in Circulation suggests a novel mechanism by which ECs, through AGO1-TSP1 pathway, control vascularization and function of adipose tissues,...
CADA members discovered a key pathway that quenches inflammation caused by overnutrition
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report...
Dr. Shuibing Chen’s latest research shows human pancreatic cells, hepatocyte and cholangiocyte organoids are permissive to SARS-CoV-2 infection
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human...